Synthesis of 2,4-Diamino-5,6,7,8,9,10-hexahydro-5,9-methanopyrimido[4,5-b]azocine
Author:
Affiliation:
1. Department of Chemistry, Princeton University, Princeton, New Jersey 08544
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo981393b
Reference20 articles.
1. Silverman, R. B.The Organic Chemistry of Drug Design and DrugAction; Academic Press: San Diego, 1992; p 159.
2. Effect of the substituent at C-6 on the biological activity of 2,4-diamino-5-(1-adamantyl) pyrimidines
3. Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
4. Trimethoprim binds in a bacterial mode to the wild-type and E30D mutant of mouse dihydrofolate reductase.
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