Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy-Reference-Cited by-同舟云学术

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy

Published:2012-01-20 Issue:3 Volume:3 Page:221-236
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Frankowski Kevin J.¹,Hedrick Michael P.²,Gosalia Palak²,Li Kelin¹,Shi Shenghua²,Whipple David¹,Ghosh Partha¹,Prisinzano Thomas E.¹,Schoenen Frank J.¹,Su Ying²,Vasile S.²,Sergienko Eduard²,Gray Wilson²,Hariharan Santosh²,Milan Loribelle²,Heynen-Genel Susanne²,Mangravita-Novo Arianna³,Vicchiarelli Michael³,Smith Layton H.³,Streicher John M.⁴,Caron Marc G.⁵,Barak Lawrence S.⁵,Bohn Laura M.⁴,Chung Thomas D. Y.²,Aubé Jeffrey¹

Affiliation:

1. University of Kansas Specialized Chemistry Center, University of Kansas, Lawrence, Kansas 66047, United States

2. Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute, La Jolla, California 92037, United States

3. Conrad Prebys Center for Chemical Genomics at Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, Florida 32827, United States

4. Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, United States

5. Department of Cell Biology, Duke University, Durham, North Carolina 27710, United States

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/cn200128x

Reference37 articles.

1. k Opioids as potential treatments for stimulant dependence

2. Kappa opioid inhibition of morphine and cocaine self-administration in rats

3. Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats

4. Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Limitations and potential of κOR biased agonists for pain and itch management;Neuropharmacology;2024-11

2. Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists;European Journal of Medicinal Chemistry;2024-10

3. Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening;Journal of Medicinal Chemistry;2024-08-01

4. Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor;Nature Communications;2023-12-06

5. Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents;Pharmaceutics;2023-05-11