Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate-Reference-Cited by-同舟云学术

Novel Vanilloid Receptor-1 Antagonists: 2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Published:2007-06-22 Issue:15 Volume:50 Page:3515-3527
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Doherty Elizabeth M.¹,Fotsch Christopher¹,Bannon Anthony W.¹,Bo Yunxin¹,Chen Ning¹,Dominguez Celia¹,Falsey James¹,Gavva Narender R.¹,Katon Jodie¹,Nixey Thomas¹,Ognyanov Vassil I.¹,Pettus Liping¹,Rzasa Robert M.¹,Stec Markian¹,Surapaneni Sekhar¹,Tamir Rami¹,Zhu Jiawang¹,Treanor James J. S.¹,Norman Mark H.¹

Affiliation:

1. Department of Chemistry Research and Discovery, Department of Neuroscience, and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070190p

Reference14 articles.

1. TRPV1 (vanilloid receptor, capsaicin receptor) agonists and antagonists

2. Novel Vanilloid Receptor-1 Antagonists: 1. Conformationally Restricted Analogues of trans-Cinnamides

3. Chakrabarti, P. P.; Chen, N.; Doherty, E. M.; Dominguez, C.; Falsey, J. R.; Fotsh, C. H.; Hulme, C.; Katon, J.; Nixey, T.; Norman, M. H.; Ognyanov, V. I.; Pettus, L. H.; Rzasa, R. M.; Stec, M.; Wang, H.L.; Zhu, J. (Amgen Inc.) Preparation of (aryloxy)pyrimidine and (aryloxy)pyridazine as vanilloid receptor ligands. WO 04014871, 2004.

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