Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors-Reference-Cited by-同舟云学术

Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors

Published:2013-10-03 Issue:20 Volume:56 Page:7838-7850
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Francotte Pierre¹,Goffin Eric¹,Fraikin Pierre¹,Graindorge E.¹,Lestage Pierre²,Danober Laurence²,Challal Sylvie²,Rogez Nathalie²,Nosjean Olivier²,Caignard Daniel-Henri²,Pirotte Bernard¹,de Tullio Pascal¹

Affiliation:

1. Centre Interfacultaire de Recherche du Médicament (CIRM)—Laboratoire de Chimie Pharmaceutique, University of Liege, Avenue de l′Hôpital 1, B36, 4000 Liège, Belgium

2. Institut de Recherches Servier, 125 Chemin de Ronde, F-78290 Croissy-sur-Seine, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400676g

Reference31 articles.

1. Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents

2. Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.

3. DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA-Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

4. Facilitation of glutamate receptors enhances memory.

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