Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Published:2012-04-18 Issue:11 Volume:3 Page:892-896
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wu Wen-Lian¹,Domalski Martin¹,Burnett Duane A.¹,Josien Hubert¹,Bara Thomas¹,Rajagopalan Murali¹,Xu Ruo¹,Clader John¹,Greenlee William J.¹,Brunskill Andrew¹,Hyde Lynn A.¹,Del Vecchio Robert A.¹,Cohen-Williams Mary E.¹,Song Lixin¹,Lee Julie¹,Terracina Giuseppe¹,Zhang Qi¹,Nomeir Amin¹,Parker Eric M.¹,Zhang Lili¹

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Neuroscience, ∥Department of Pharmaceutical Sciences, and §Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300044f

Reference25 articles.

1. Alzheimer's Disease

2. Alzheimer's Disease: The Amyloid Cascade Hypothesis

3. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

4. The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

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