Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

Published:2014-09-08 Issue:10 Volume:5 Page:1088-1093
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Tao Zhi-Fu¹,Hasvold Lisa¹,Wang Le¹,Wang Xilu¹,Petros Andrew M.¹,Park Chang H.¹,Boghaert Erwin R.¹,Catron Nathaniel D.¹,Chen Jun¹,Colman Peter M.²³,Czabotar Peter E.²³,Deshayes Kurt⁴,Fairbrother Wayne J.⁴,Flygare John A.⁴,Hymowitz Sarah G.⁴,Jin Sha¹,Judge Russell A.¹,Koehler Michael F. T.⁴,Kovar Peter J.¹,Lessene Guillaume²³⁵,Mitten Michael J.¹,Ndubaku Chudi O.⁴,Nimmer Paul¹,Purkey Hans E.⁴,Oleksijew Anatol¹,Phillips Darren C.¹,Sleebs Brad E.²³,Smith Brian J.²³,Smith Morey L.¹,Tahir Stephen K.¹,Watson Keith G.²³,Xiao Yu¹,Xue John¹,Zhang Haichao¹,Zobel Kerry⁴,Rosenberg Saul H.¹,Tse Chris¹,Leverson Joel D.¹,Elmore Steven W.¹,Souers Andrew J.¹

Affiliation:

1. AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064 United States

2. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia

3. Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia

4. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 United States

5. Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3010, Australia

Funder

Genentech

National Health and Medical Research Council

Australian Cancer Research Foundation

Australian Research Council

AbbVie

Leukemia and Lymphoma Society

Cancer Council Victoria

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml5001867

Reference20 articles.

1. The Hallmarks of Cancer

2. The Bcl-2 apoptotic switch in cancer development and therapy

3. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

4. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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