Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor-Reference-Cited by-同舟云学术

Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

Published:2012-10-16 Issue:20 Volume:55 Page:8770-8789
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cid Jose María¹²,Tresadern Gary¹²,Vega Juan Antonio¹²,de Lucas Ana Isabel¹²,Matesanz Encarnación¹²,Iturrino Laura¹²,Linares María Lourdes¹²,Garcia Aránzazu¹²,Andrés José Ignacio¹²,Macdonald Gregor J.¹²,Oehlrich Daniel¹²,Lavreysen Hilde¹²,Megens Anton¹²,Ahnaou Abdellah¹²,Drinkenburg Wilhelmus¹²,Mackie Claire¹²,Pype Stefan¹²,Gallacher David¹²,Trabanco Andrés A.¹²

Affiliation:

1. Neuroscience Medicinal Chemistry and ‡Molecular Sciences, Janssen Research & Development, Janssen-Cilag S.A., Jarama 75, 45007 Toledo, Spain

2. Neuroscience Medicinal Chemistry, ∥Neuroscience Biology, ⊥Discovery ADME/Tox, #Project Management Office, and ∞Center of Excellence for Cardiovascular Safety Research & Mechanistic Pharmacology, Janssen Research & Development, Turnhoutseweg 30, B-2340, Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3010724

Reference54 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

2. Mood disorders: Regulation by metabotropic glutamate receptors

3. Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

4. Metabotropic glutamate receptors as therapeutic targets for schizophrenia

5. Metabotropic glutamate receptors and the control of chronic pain

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