How a β-d-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties-Reference-Cited by-同舟云学术

How a β-d-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study, and Evaluation of Antithrombotic Properties

Published:2014-10-14 Issue:20 Volume:57 Page:8563-8575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Belviso Benny D.¹,Caliandro Rocco¹,de Candia Modesto²,Zaetta Giorgia²,Lopopolo Gianfranco²,Incampo Francesca³,Colucci Mario³,Altomare Cosimo D.²

Affiliation:

1. Institute of Crystallography, Consiglio Nazionale delle Ricerche, Via Amendola 122/o, 70126 Bari, Italy

2. Department of Pharmacy—Drug Sciences, University of Bari ‘‘Aldo Moro’’, Via E. Orabona 4, 70125 Bari, Italy

3. Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, Piazza Giulio Cesare 11, 70124 Bari, Italy

Funder

Collezione Nazionale dei Composti Chimici e Centro Screening

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5010754

Reference40 articles.

1. Novel Oral Anticoagulants

2. New oral Xa and IIa inhibitors: updates on clinical trial results

3. Pharmacological Strategies for Inhibition of Thrombin Activity

4. Practical Considerations in the Use of Novel Oral Anticoagulants for Stroke Prevention in Nonvalvular Atrial Fibrillation

5. New Oral Anticoagulants in Practice: Pharmacological and Practical Considerations

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