Development of an Efficient and Practical Route for the Multikilogram Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate and Ethyl 6-Chloro-5-cyano-2-methylnicotinate, Key Intermediates in the Preparation of P2Y12 Antagonists-Reference-Cited by-同舟云学术

Development of an Efficient and Practical Route for the Multikilogram Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate and Ethyl 6-Chloro-5-cyano-2-methylnicotinate, Key Intermediates in the Preparation of P2Y12 Antagonists

Published:2012-05-01 Issue:5 Volume:16 Page:819-823
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Bell Stephen J.¹,McIntyre Steve¹,Garcia Conchita F.¹,Kitson Sean L¹,Therkelsen Frans¹,Andersen Søren M²,Zetterberg Fredrik²,Aurell Carl-Johan³,Bollmark Martin³,Ehrl Robert³

Affiliation:

1. Almac, Almac House, 20 Seagoe Industrial Estate, Craigavon, Northern Ireland BT63 5QD, United Kingdom

2. Astrazeneca R&D, Mölndal, Sweden

3. Pharmaceutical Development, AstraZeneca R&D, Södertälje, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200368m

Reference6 articles.

1. aAndersen, S.; Bach, P.r; Brickmann, K.; Giordanetto, F.; Zetterberg, F.; Oesterlund, K.Pyridine analogues as P2Y12 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of platelet aggregation disorders. PCT Int. Appl. WO/2007/008140, 2007.

2. bAntonsson, T.; Bach, P.; Brickmann, K.; Bylund, R.; Giordanetto, F.; Johansson, J.; Zetterberg, F.PCT Int Appl. WO/2008/085118, 2008.

3. cBylund, R.; Hovdal, D.; Johansson, J.; Sellen, M.; Zetterberg, F.PCT Int Appl. WO/2010/005385, 2010.

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