Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones-Reference-Cited by-同舟云学术

Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones

Published:2001-07-04 Issue:16 Volume:44 Page:2523-2535
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Van der Mey Margaretha¹,Hatzelmann Armin¹,Van Klink Gerard P. M.¹,Van der Laan Ivonne J.¹,Sterk Geert J.¹,Thibaut Ulrich¹,Ulrich Wolf R.¹,Timmerman Hendrik¹

Affiliation:

1. Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Department of Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands; Byk Nederland, Zwanenburg, The Netherlands; and Byk Gulden, Konstanz, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010838c

Reference42 articles.

1. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

2. Isolation and Characterization of PDE8A, a Novel Human cAMP-Specific Phosphodiesterase

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