Design, Synthesis, and Biological Evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as New Indole-Based Cytosolic Phospholipase A2α Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic Acids as New Indole-Based Cytosolic Phospholipase A2α Inhibitors

Published:2014-08-26 Issue:17 Volume:57 Page:7244-7262
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tomoo Toshiyuki¹,Nakatsuka Takashi¹,Katayama Toyoko¹,Hayashi Yasuhiro¹,Fujieda Yusuke¹,Terakawa Maki¹,Nagahira Kazuhiro¹

Affiliation:

1. Faculty of Pharmaceutical Chemistry, ‡R&D Administration, §Exploratory Technology, ∥Drug Discovery Technology, and ⊥Pharmacology I, Asubio Pharma Co., Ltd., 6-4-3 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500494y

Reference83 articles.

1. The expanding superfamily of phospholipase A2 enzymes: classification and characterization

2. Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

3. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

4. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2

5. Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: Application to the determination of substrate preferences

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. N,N-Disubstituted 4-Sulfamoylbenzoic Acid Derivatives as Inhibitors of Cytosolic Phospholipase A_2α: Synthesis, Aqueous Solubility, and Activity in a Vesicle and a Whole Blood Assay;Medicinal Chemistry;2024-12

2. Visible-light-induced trifluoromethylation/cyclization of unactivated alkenes: Synthesis of CF3-substituted fused tricyclic indoles;Tetrahedron Letters;2024-09

3. Synthesis, structure–activity relationship and biological evaluation of indole derivatives as anti-Candida albicans agents;Bioorganic Chemistry;2024-05

4. 1-Benzylindoles as inhibitors of cytosolic phospholipase A₂α: synthesis, biological activity, aqueous solubility, and cell permeability;RSC Medicinal Chemistry;2024

5. Design and Synthesis of Novel Indole Ethylamine Derivatives as a Lipid Metabolism Regulator Targeting PPARα/CPT1 in AML12 Cells;Molecules;2023-12-19