Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Author:

Keenan Martine1,Abbott Michael J.1,Alexander Paul W.1,Armstrong Tanya2,Best Wayne M.1,Berven Bradley1,Botero Adriana2,Chaplin Jason H.1,Charman Susan A.3,Chatelain Eric4,von Geldern Thomas W.4,Kerfoot Maria2,Khong Andrea2,Nguyen Tien3,McManus Joshua D.1,Morizzi Julia3,Ryan Eileen3,Scandale Ivan4,Thompson R. Andrew2,Wang Sen Z.1,White Karen L.3

Affiliation:

1. Epichem Pty Ltd, South Street, Murdoch, WA 6150, Australia

2. Murdoch University, South Street, Murdoch, WA 6150, Australia

3. Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

4. Drugs for Neglected Diseases initiative (DNDi), 15 Chemin Louis Dunant, 1202 Geneva, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference37 articles.

1. Chagas Disease (American Trypanosomiasis), Fact Sheet no. 340;World Health Organisation:Geneva, 2010; http://www.who.int.mediacentre/factsheets/fs340/en/index.html(Accessed September 7, 2011).

2. New, Improved Treatments for Chagas Disease: From the R&D Pipeline to the Patients

3. Conrad et al. reply

4. Anti-T. cruzi Agents: Our Experience in the Evaluation of More than Five Hundred Compounds

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