N-[ω-(Tetralin-1-yl)alkyl] Derivatives of 3,3-Dimethylpiperidine Are Highly Potent and Selective σ1 or σ2 Ligands-Reference-Cited by-同舟云学术

N-[ω-(Tetralin-1-yl)alkyl] Derivatives of 3,3-Dimethylpiperidine Are Highly Potent and Selective σ1 or σ2 Ligands

Published:1998-09-18 Issue:21 Volume:41 Page:3940-3947
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Berardi Francesco¹,Santoro Sergio¹,Perrone Roberto¹,Tortorella Vincenzo¹,Govoni Stefano¹,Lucchi Laura¹

Affiliation:

1. Dipartimento Farmaco-Chimico, Università di Bari, via Orabona, 4, 70126 Bari, Italy, Istituto di Farmacologia, Università di Pavia, via Taramelli, 12, 27100 Pavia, Italy, and Istituto di Scienze Farmacologiche, Università di Milano, via Balzaretti, 9, 20133 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970692a

Reference44 articles.

1. Modulation of nmda and dopaminergic neurotransmissions by sigma ligands: Possible implications for the treatment of psychiatric disorders

2. BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide as potent and isoform selective ROCK2 inhibitors;Bioorganic & Medicinal Chemistry;2019-04

2. Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ1 receptor ligands;Bioorganic & Medicinal Chemistry;2011-12

3. Exploring the Importance of Piperazine N-Atoms for σ2 Receptor Affinity and Activity in a Series of Analogs of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28);Journal of Medicinal Chemistry;2009-10-20

4. Intramolecular Photoarylation of Alkenes by Phenyl Cations;Chemistry - A European Journal;2006-05-03

5. A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands;ChemMedChem;2006-01-16