Design, Synthesis, and Evaluation of a Novel Sequence-Selective Epoxide-Containing DNA Cross-Linking Agent Based on the Pyrrolo[2,1-c][1,4]benzodiazepine System-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of a Novel Sequence-Selective Epoxide-Containing DNA Cross-Linking Agent Based on the Pyrrolo[2,1-c][1,4]benzodiazepine System

Published:1999-09-16 Issue:20 Volume:42 Page:4028-4041
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wilson Stuart C.¹,Howard Philip W.¹,Forrow Stephen M.¹,Hartley John A.¹,Adams Lesley J.¹,Jenkins Terence C.¹,Kelland Lloyd R.¹,Thurston David E.¹

Affiliation:

1. CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth, Hants. PO1 2DT, U.K., CRC Drug-DNA Interactions Research Group, Department of Oncology, University College London Medical School, London W1P 8BT, U.K., School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London SE18 6PF, U.K., and CRC Centre for Cancer Therapeutics, Institute of Cancer Research,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981124d

Reference59 articles.

1. Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer

2. Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

3. A Structural Basis for Recognition of A·T and T·A Base Pairs in the Minor Groove of B-DNA

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