Development of a Catalytic Cuprate 1,6-Conjugate Dienone Addition Process for the Manufacture of Fulvestrant EAS, a Key Intermediate in the Synthesis of Fulvestrant-Reference-Cited by-同舟云学术

Development of a Catalytic Cuprate 1,6-Conjugate Dienone Addition Process for the Manufacture of Fulvestrant EAS, a Key Intermediate in the Synthesis of Fulvestrant

Published:2010-07-23 Issue:5 Volume:14 Page:1188-1193
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hogan Philip J.¹,Powell Lyn¹,Robinson Graham E.¹

Affiliation:

1. Process Chemistry Department, AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire SK10, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op1001319

Reference51 articles.

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4. Fulvestrant: From the Laboratory to Commercial-Scale Manufacture

5. Organocopper(I) Compounds and Organocuprates in Synthesis

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