Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance and Tumor Uptake with Improved 64-Copper PET Imaging-Reference-Cited by-同舟云学术

Site-Specific Conjugation of Monodispersed DOTA-PEGn to a Thiolated Diabody Reveals the Effect of Increasing PEG Size on Kidney Clearance and Tumor Uptake with Improved 64-Copper PET Imaging

Published:2011-03-24 Issue:4 Volume:22 Page:709-716
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Li Lin¹,Crow Desiree²,Turatti Fabio³,Bading James R.²,Anderson Anne-Line²,Poku Erasmus²,Yazaki Paul J.²,Carmichael Jenny³,Leong David³,Wheatcroft Michael P.³,Raubitschek Andrew A.²,Hudson Peter J.³,Colcher David²,Shively John E.¹

Affiliation:

1. Department of Immunology, Beckman Research Institute of City of Hope, Duarte, California 91010, United States

2. Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute of City of Hope, Duarte, California 91010, United States

3. Avipep Pty Ltd., 343 Royal Parade, Parkville VIC 3008, Australia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc100464e

Reference31 articles.

1. Antibodies for Molecular Imaging of Cancer

2. Numerical Selection of Optimal Tumor Imaging Agents with Application to Engineered Antibodies

3. Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation

4. Monodispersed DOTA-PEG–Conjugated Anti-TAG-72 Diabody Has Low Kidney Uptake and High Tumor-to-Blood Ratios Resulting in Improved64Cu PET

5. Vinyl Sulfone Bifunctional Derivatives of DOTA Allow Sulfhydryl- or Amino-Directed Coupling to Antibodies. Conjugates Retain Immunoreactivity and Have Similar Biodistributions

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