The Vinblastine Binding Site Adopts High- and Low-Affinity Conformations during a Transport Cycle of P-glycoprotein-Reference-Cited by-同舟云学术

The Vinblastine Binding Site Adopts High- and Low-Affinity Conformations during a Transport Cycle of P-glycoprotein

Published:2001-12-01 Issue:51 Volume:40 Page:15733-15742
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Martin Catherine¹,Higgins Christopher F.¹,Callaghan Richard¹

Affiliation:

1. Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, U.K., and MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi011211z

Reference50 articles.

1. Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

2. Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

3. Secondary and Tertiary Structure Changes of Reconstituted P-glycoprotein

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