Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists-Reference-Cited by-同舟云学术

Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists

Published:2012-01-24 Issue:3 Volume:55 Page:1368-1381
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ibrahim Mohamed A.¹,Johnson Henry W. B.¹,Jeong Joon Won¹,Lewis Gary L.¹,Shi Xian¹,Noguchi Robin T.¹,Williams Matthew¹,Leahy James W.¹,Nuss John M.¹,Woolfrey John¹,Banica Monica¹,Bentzien Frauke¹,Chou Yu-Chien¹,Gibson Anna¹,Heald Nathan¹,Lamb Peter¹,Mattheakis Larry¹,Matthews David¹,Shipway Aaron¹,Wu Xiang¹,Zhang WenTao¹,Zhou Sihong¹,Shankar Geetha¹

Affiliation:

1. Department of Drug Discovery, Exelixis, 169 Harbor Way, South San Francisco, California 94083, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201533b

Reference22 articles.

1. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

2. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

3. Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor