1. Dipartimento di Scienze Farmaceutiche, Università di Bologna, Via Belmeloro 6, 40126 Bologna, Italy, Dipartimento di Biochimica “G. Moruzzi”, Università di Bologna, Via Irnerio 48, 40126 Bologna, Italy, Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, and Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, Frederick, Maryland 21702