Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps-Reference-Cited by-同舟云学术

Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps

Published:2013-10-30 Issue:12 Volume:4 Page:1169-1172
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Achenbach Janosch¹,Klingler Franca-Maria¹,Blöcher René¹,Moser Daniel¹,Häfner Ann-Kathrin¹,Rödl Carmen B.¹,Kretschmer Simon¹,Krüger Björn²,Löhr Frank³,Stark Holger¹,Hofmann Bettina¹,Steinhilber Dieter¹,Proschak Ewgenij¹

Affiliation:

1. Institute of Pharmaceutical Chemistry, ZAFES/OSF, Goethe University, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany

2. Chemical R&D—Drug Design, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, D-60318 Frankfurt, Germany

3. Institute of Biophysical Chemistry, Goethe University, Max-von-Laue Strasse 9, D-60438 Frankfurt am Main, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml4002562

Reference30 articles.

1. Lethality and centrality in protein networks

2. Multi-target therapeutics: when the whole is greater than the sum of the parts

3. From magic bullets to designed multiple ligands

4. Designed Multiple Ligands. An Emerging Drug Discovery Paradigm

5. The role of fragment-based and computational methods in polypharmacology

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