Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma-Reference-Cited by-同舟云学术

Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma

Published:2014-12-03 Issue:1 Volume:58 Page:347-361
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tintori Cristina¹,Fallacara Anna Lucia¹²,Radi Marco¹,Zamperini Claudio¹,Dreassi Elena¹,Crespan Emmanuele³,Maga Giovanni³,Schenone Silvia⁴,Musumeci Francesca⁴,Brullo Chiara⁴,Richters André⁵,Gasparrini Francesca⁶,Angelucci Adriano⁷,Festuccia Claudio⁷,Delle Monache Simona⁷,Rauh Daniel⁵,Botta Maurizio¹⁸

Affiliation:

1. Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena Via Aldo Moro 2, 53100 Siena, Italy

2. Dipartimento di Chimica e Tecnologie Farmaceutiche, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy

3. Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy

4. Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy

5. Department of Chemistry and Chemical Biology, Technical University of Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany

6. Dipartimento di Medicina Molecolare, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy

7. Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell’Aquila, Via Vetoio, 67100 Coppito, L’Aquila, Italy

8. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, United States

Funder

European Cooperation in Science and Technology

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Lead Discovery Siena

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5013159

Reference63 articles.

1. Surveillance, Epidemiology and End Results Database;National Cancer Institute:Bethesda, MD;http://seer.cancer.gov(accessed November 2005).