Design, Synthesis, and Evaluation of Inhibitors of Trypanosomal and Leishmanial Dihydrofolate Reductase-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Inhibitors of Trypanosomal and Leishmanial Dihydrofolate Reductase

Published:1999-10-01 Issue:21 Volume:42 Page:4300-4312
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chowdhury Shafinaz F.¹,Villamor Victor Bernier¹,Guerrero Ramon Hurtado¹,Leal Isabel¹,Brun Reto¹,Croft Simon L.¹,Goodman Jonathan M.¹,Maes Louis¹,Ruiz-Perez Luis M.¹,Pacanowska Dolores Gonzalez¹,Gilbert Ian H.¹

Affiliation:

1. Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, U.K., Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, C/Ventanilla 11, 18001-Granada, Spain, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K., Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., and Tibotec n.v.,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981130%2B

Reference15 articles.

1. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

2. Concomitant changes of ethanol partitioning and disordering capacities in rat synaptic membranes

3. Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors

4. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth

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