Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)-Reference-Cited by-同舟云学术

Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)

Published:2011-10-03 Issue:20 Volume:54 Page:7318-7333
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Weinstein David S.¹,Gong Hua¹,Doweyko Arthur M.¹,Cunningham Mark¹,Habte Sium¹,Wang Jin Hong¹,Holloway Deborah A.¹,Burke Christine¹,Gao Ling¹,Guarino Victor¹,Carman Julie¹,Somerville John E.¹,Shuster David¹,Salter-Cid Luisa¹,Dodd John H.¹,Nadler Steven G.¹,Barrish Joel C.¹

Affiliation:

1. Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200879j

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2. Optimised glucocorticoid therapy: the sharpening of an old spear

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