Synthesis of Conformationally Constrained 5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine Inhibitors of Farnesyltransferase-Reference-Cited by-同舟云学术

Synthesis of Conformationally Constrained 5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine Inhibitors of Farnesyltransferase

Published:2000-10-10 Issue:22 Volume:2 Page:3473-3476
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Dinsmore Christopher J.¹,Zartman C. Blair¹,Baginsky Walter F.¹,O'Neill Timothy J.¹,Koblan Kenneth S.¹,Chen I-Wu¹,McLoughlin Debra A.¹,Olah Timothy V.¹,Huff Joel R.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cancer Research, and Drug Metabolism, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol0002424

Reference21 articles.

1. Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

2. Anticancer drug targets: growth factors and growth factor signaling

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