Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis
Author:
Affiliation:
1. Center for Pharmaceutical Studies, University of Coimbra, Portugal
2. Faculdade de Farmácia, Universidade de Coimbra, 3000-548 Coimbra, Portugal
3. Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm1007769
Reference25 articles.
1. Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
2. Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
3. Interactions of oxysterols with membranes and proteins
4. Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells
5. Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects
Cited by 59 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Steroidal hydrazones as antimicrobial agents: biological evaluation and molecular docking studies;SAR and QSAR in Environmental Research;2024-02-05
2. Oxysterols as Biomarkers of Aging and Disease;Implication of Oxysterols and Phytosterols in Aging and Human Diseases;2023-12-01
3. Effects of 7-ketocholesterol on tamoxifen efficacy in breast carcinoma cell line models in vitro;The Journal of Steroid Biochemistry and Molecular Biology;2023-09
4. Semi-Synthesis and Biological Evaluation of 25(R)-26-Acetoxy-3β,5α-Dihydroxycholest-6-One;Marine Drugs;2023-03-20
5. Oxysterols in catfish skin secretions (Arius bilineatus, Val.) exhibit anti-cancer properties;Frontiers in Pharmacology;2022-10-14
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3