Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics-Reference-Cited by-同舟云学术

Identification of a Pharmacophore for Thrombopoietic Activity of Small, Non-Peptidyl Molecules. 1. Discovery and Optimization of Salicylaldehyde Thiosemicarbazone Thrombopoietin Mimics

Published:2002-07-19 Issue:17 Volume:45 Page:3573-3575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Duffy Kevin J.¹,Shaw Anthony N.¹,Delorme Evelyne¹,Dillon Susan B.¹,Erickson-Miller Connie¹,Giampa Leslie¹,Huang Yifang¹,Keenan Richard M.¹,Lamb Peter¹,Liu Nannan¹,Miller Stephen G.¹,Price Alan T.¹,Rosen Jon¹,Smith Heather¹,Wiggall Kenneth J.¹,Zhang Lihua¹,Luengo Juan I.¹

Affiliation:

1. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, and Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm025535c

Reference17 articles.

1. Kuter, D. J.; Hunt, P.; Sheridan, W.; Zucker-Franklin, D.Thrombopoiesis andthrombopoietins: molecular, cellular, preclinical, and clinical biology; Humana: Totowa, NJ, 1997; p 412.

2. Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

3. Thrombopoietin Signal Transduction: Studies from Cell Lines and Primary Cells

4. Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

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