Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase-Reference-Cited by-同舟云学术

Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

Published:2013-11-06 Issue:5 Volume:57 Page:1914-1931
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Talamas Francisco X.¹,Abbot Sarah C.¹,Anand Shalini¹,Brameld Ken A.¹,Carter David S.¹,Chen Jun¹,Davis Dana¹,de Vicente Javier¹,Fung Amy D.¹,Gong Leyi¹,Harris Seth F.¹,Inbar Petra¹,Labadie Sharada S.¹,Lee Eun K.¹,Lemoine Remy¹,Le Pogam Sophie¹,Leveque Vincent¹,Li Jim¹,McIntosh Joel¹,Nájera Isabel¹,Park Jaehyeon¹,Railkar Aruna¹,Rajyaguru Sonal¹,Sangi Michael¹,Schoenfeld Ryan C.¹,Staben Leanna R.¹,Tan Yunchou¹,Taygerly Joshua P.¹,Villaseñor Armando G.¹,Weller Paul E.¹

Affiliation:

1. Pharma Research and Early Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401329s

Reference34 articles.

1. World Health Organization. Media Centre. Hepatitis C.http://www.who.int/mediacentre/factsheets/fs164/en/(accessed May 17, 2013) .

2. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

3. EASL Clinical Practice Guidelines: Management of hepatitis C virus infection