Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models-Reference-Cited by-同舟云学术

Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models

Published:2010-10-08 Issue:21 Volume:53 Page:7739-7755
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Payne Joseph E.¹,Bonnefous Céline¹,Symons Kent T.²,Nguyen Phan M.²,Sablad Marciano³,Rozenkrants Natasha³,Zhang Yan³,Wang Li⁴,Yazdani Nahid⁵,Shiau Andrew K.²,Noble Stewart A.¹,Rix Peter⁴,Rao Tadimeti S.³,Hassig Christian A.²,Smith Nicholas D.¹

Affiliation:

1. Department of Chemistry

2. Department of Biology

3. Department of Pharmacology

4. Department of Drug Metabolism and Pharmacokinetics

5. Department of Analytical Chemistry

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100828n