Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations-Reference-Cited by-同舟云学术

Molecular Mechanism of the Effects of Salt and pH on the Affinity between Protein A and Human Immunoglobulin G1 Revealed by Molecular Simulations

Published:2011-12-19 Issue:1 Volume:116 Page:424-433
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Huang Bo¹,Liu Fu-Feng¹,Dong Xiao-Yan¹,Sun Yan¹

Affiliation:

1. Department of Biological Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp205770p

Reference58 articles.

1. Antibody purification with protein A attached supermacroporous poly(hydroxyethyl methacrylate) cryogel

2. Purification of antibody and antibody-fragment fromE. coli homogenate using 6,9-diamino-2-ethoxyacridine lactate as precipitation agent

3. Ion exchange chromatography of antibody fragments

4. Integrated process for the purification of antibodies combining aqueous two-phase extraction, hydrophobic interaction chromatography and size-exclusion chromatography

5. Affinity-based methodologies and ligands for antibody purification: Advances and perspectives

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