Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxyphenoxy)ethyl][(3-p-tolyl-2,3-dihydro-1,4- benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive α1A-Adrenoreceptor Antagonist-Reference-Cited by-同舟云学术

Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxyphenoxy)ethyl][(3-p-tolyl-2,3-dihydro-1,4- benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive α1A-Adrenoreceptor Antagonist

Published:1996-01-01 Issue:11 Volume:39 Page:2253-2258
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Quaglia Wilma¹,Pigini Maria¹,Tayebati Seyed K.¹,Piergentili Alessandro¹,Giannella Mario¹,Leonardi Amedeo¹,Taddei Carlo¹,Melchiorre Carlo¹

Affiliation:

1. Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy, Research and Development Division, Recordati S.p.A., Via Civitali 1, 20148 Milano, Italy, and Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960069a

Reference30 articles.

1. BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors

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3. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

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