Further Studies on the Dmt-Tic Pharmacophore: Hydrophobic Substituents at the C-Terminus Endow δ Antagonists To Manifest μ Agonism or μ Antagonism-Reference-Cited by-同舟云学术

Further Studies on the Dmt-Tic Pharmacophore: Hydrophobic Substituents at the C-Terminus Endow δ Antagonists To Manifest μ Agonism or μ Antagonism

Published:1999-11-10 Issue:24 Volume:42 Page:5010-5019
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Salvadori Severo¹,Guerrini Remo¹,Balboni Gianfranco¹,Bianchi Clementina¹,Bryant Sharon D.¹,Cooper Peter S.¹,Lazarus Lawrence H.¹

Affiliation:

1. Department of Pharmaceutical Science and Biotechnology Center, University of Ferrara, I-441000 Ferrara, Italy, Institute of Pharmacology, University of Ferrara, I-44100 Ferrara, Italy, Peptide Neurochemistry, LCBRA, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, and National Center for Biotechnology Information, National Library of Medicine, Building 38A, 8600 Rockville Pike, Bethesda, Maryland 20894

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990165m

Reference71 articles.

1. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

2. TIPP[.psi.]: a highly potent and stable pseudopeptide .delta. opioid receptor antagonist with extraordinary .delta. selectivity

3. (c) Schiller, P. W.; Nguyen, T. M.D.; Weltrowska, G.; Wilkes, B. C.; Marsden, B. J.; Schmidt, R.; Lemieux, C.; Chung, N. N. TIPP opioid peptides: development of extraordinarily potent and selective δ antagonists and observation of astonishing structure-intrinsic activity relationships.Peptides; Hodges, R. S., Smith, J. A., Eds.; ESCOM, 1994; pp 483−486.

4. Selective Opioid Dipeptides

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