1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands, Division of Biopharmacy and Pharmacokinetics, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland, and Drug Discovery and Development Technology Center, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland