Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation-Reference-Cited by-同舟云学术

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

Published:2014-03-03 Issue:3 Volume:18 Page:423-430
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Song Zhiguo J.¹,Tellers David M.¹,Dormer Peter G.¹,Zewge Daniel¹,Janey Jacob M.¹,Nolting Andrew¹,Steinhuebel Dietrich¹,Oliver Steven¹,Devine Paul N.¹,Tschaen David M.¹

Affiliation:

1. Department of Process Chemistry, Merck Research Laboratory, P.O. Box 2000, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400331j

Reference28 articles.

1. Advances in the Development of Macrocyclic Inhibitors of Hepatitis C Virus NS3-4A Protease

2. Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections

3. Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

4. Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

5. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

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