Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode
Author:
Affiliation:
1. Merck Research Laboratories, 320 Bent Street, Cambridge, Massachusetts 02141, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml200249h
Reference34 articles.
1. Global cancer statistics
2. DNA and its associated processes as targets for cancer therapy
3. The DNA damage response: putting checkpoints in perspective
4. Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents
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