1. Contribution from the Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba Science City, 305-8562, Japan, iGENE Therapeutics, Inc., c/o AIST, Central 4, 1-1-1 Higashi, Tsukuba Science City, 305-8562, Japan, and Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Tokyo 113-8656, Japan