Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis-Reference-Cited by-同舟云学术

Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

Published:2012-02-13 Issue:7 Volume:55 Page:2915-2931
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pettipher Roy¹,Whittaker Mark²

Affiliation:

1. Oxagen Ltd., 91 Milton Park, Abingdon, Oxon OX14 4RY, U.K.

2. Evotec (U.K.) Ltd 114 Milton Park Abingdon Oxon OX14 4SA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2013997

Reference118 articles.

1. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases

3. Novel CRTH2 antagonists: a review of patents from 2006 to 2009

4. DP2receptor antagonists in development

5. Prostaglandin D2 Receptor CRTH2 Antagonists for the Treatment of Inflammatory Diseases

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