Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)-Reference-Cited by-同舟云学术

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

Published:2014-04-11 Issue:8 Volume:57 Page:3570-3587
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chapman Timothy M.¹,Osborne Simon A.¹,Wallace Claire¹,Birchall Kristian¹,Bouloc Nathalie¹,Jones Hayley M.¹,Ansell Keith H.¹,Taylor Debra L.¹,Clough Barbara²,Green Judith L.²,Holder Anthony A.²

Affiliation:

1. Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, U.K.

2. Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500342d

Reference26 articles.

1. World Malaria Report, 2010; World Health Organization. www.who.int/malaria/publications/atoz/9789241564106/en/index.html.

2. Drug-resistant malaria: Molecular mechanisms and implications for public health

3. Plants, symbiosis and parasites: a calcium signalling connection

4. Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

5. Gene structure and expression of an unusual protein kinase from Plasmodium falciparum homologous at its carboxyl terminus with the EF hand calcium-binding proteins.

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