Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)
Author:
Affiliation:
1. Centre for Therapeutics Discovery, MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, U.K.
2. Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U.K.
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm500342d
Reference26 articles.
1. World Malaria Report, 2010; World Health Organization. www.who.int/malaria/publications/atoz/9789241564106/en/index.html.
2. Drug-resistant malaria: Molecular mechanisms and implications for public health
3. Plants, symbiosis and parasites: a calcium signalling connection
4. Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote
5. Gene structure and expression of an unusual protein kinase from Plasmodium falciparum homologous at its carboxyl terminus with the EF hand calcium-binding proteins.
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