cis-Dichloro(α,ω-diamino carboxylate ethyl ester)palladium(II) as Palladium(II) versus Platinum(II) Model Anticancer Drugs:  Synthesis, Solution Equilibria of Their Aqua, Hydroxo, and/or Chloro Species, and in Vitro/in Vivo DNA-Binding Properties

Author:

González M. L.1,Tercero J. M.1,Matilla A.1,Niclós-Gutiérrez J.1,Fernández M. T.1,López M. C.1,Alonso C.1,González S.1

Affiliation:

1. Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Granada, E-18071 Granada, Spain, Instituto de Parasitología y Biomedicina “López-Neyra” (CSIC), Granada, Spain, and Centro de Biología Molecular “Severo Ochoa” (CSIC), Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

Reference34 articles.

1. Brown, S. J.; Chow, Ch. S.; Lippard, S. J. InEncyclopedia ofInorganic Chemistry; King, R. B., Ed.; Wiley:  New York−Chichester, 1994; pp 3305−3315, and references cited therein.

2. Chemistry and molecular biology of platinum anticancer drugs

3. Platinum amine coordination compounds as anti-tumor drugs. Molecular aspects of the mechanism of action

4. The nature of cis amine Pd(II) and antitumor cis amine Pt(II) complexes in aqueous solutions

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