Protein–Ligand Cocrystal Structures: We Can Do Better
Author:
Affiliation:
1. Gfree Bio, LLC, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml500220a
Reference10 articles.
1. Conformational changes of small molecules binding to proteins
2. Application and Limitations of X-ray Crystallographic Data in Structure-Based Ligand and Drug Design
3. The good, the bad and the twisted: a survey of ligand geometry in protein crystal structures
4. PDB Ligand Conformational Energies Calculated Quantum-Mechanically
5. Conformational Analysis of Drug-Like Molecules Bound to Proteins: An Extensive Study of Ligand Reorganization upon Binding
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