Synthesis and Structure−Activity Relationship of Novel, Highly Potent Metharyl and Methcycloalkyl Cyclooxygenase-2 (COX-2) Selective Inhibitors

Author:

Khanapure Subhash P.1,Garvey David S.1,Young Delano V.1,Ezawa Maiko1,Earl Richard A.1,Gaston Rick D.1,Fang Xinqin1,Murty Madhavi1,Martino Allison1,Shumway Matthew1,Trocha Mark1,Marek Przemyslaw1,Tam S. William1,Janero David R.1,Letts L. Gordon1

Affiliation:

1. NitroMed, Inc., 12 Oak Park Drive, Bedford, Massachusetts 01730

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference57 articles.

1. Vane, J. R.; Botting, R. M.Therapeutic Roles of Selective COX-2Inhibitors; William Harvey Press:  London, UK, 2001; pp 1−548.

2. Ford-Hutchinson, A. W. Evidence for the Involvement of Leukotrienes and Other Lipoxygenase Products in Disease States. Chapter 5.Leukotrienes and Lipoxygenases:  Chemical, Biological and ClinicalAspects; Rokach, J., Ed.; Elsevier Press:  Amsterdam, 1989; pp 407−410.

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