Synthesis and Structure−Activity Relationship of Novel, Highly Potent Metharyl and Methcycloalkyl Cyclooxygenase-2 (COX-2) Selective Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationship of Novel, Highly Potent Metharyl and Methcycloalkyl Cyclooxygenase-2 (COX-2) Selective Inhibitors

Published:2003-11-07 Issue:25 Volume:46 Page:5484-5504
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Khanapure Subhash P.¹,Garvey David S.¹,Young Delano V.¹,Ezawa Maiko¹,Earl Richard A.¹,Gaston Rick D.¹,Fang Xinqin¹,Murty Madhavi¹,Martino Allison¹,Shumway Matthew¹,Trocha Mark¹,Marek Przemyslaw¹,Tam S. William¹,Janero David R.¹,Letts L. Gordon¹

Affiliation:

1. NitroMed, Inc., 12 Oak Park Drive, Bedford, Massachusetts 01730

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030268b

Reference57 articles.

1. Vane, J. R.; Botting, R. M.Therapeutic Roles of Selective COX-2Inhibitors; William Harvey Press: London, UK, 2001; pp 1−548.

2. Ford-Hutchinson, A. W. Evidence for the Involvement of Leukotrienes and Other Lipoxygenase Products in Disease States. Chapter 5.Leukotrienes and Lipoxygenases: Chemical, Biological and ClinicalAspects; Rokach, J., Ed.; Elsevier Press: Amsterdam, 1989; pp 407−410.

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