Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture

Author:

Louati Kaouthar1ORCID,Maalej Amina2,Kolsi Fatma34,Kallel Rim54,Gdoura Yassine34,Borni Mahdi34,Hakim Leila Sellami5,Zribi Rania6,Choura Sirine2,Sayadi Sami7,Chamkha Mohamed2,Mnif Basma84,Khemakhem Zouheir94,Boudawara Tahya Sellami54,Boudawara Mohamed Zaher34,Safta Fathi1

Affiliation:

1. Faculty of Pharmacy, Laboratory of Pharmacology, Analytics & Galenic Drug Development-LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia

2. Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia

3. Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia

4. Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia

5. Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia

6. Higher Institute of Applied Studies to Humanities of Tunis (ISEAHT), University of Tunis, 11 Road of Jebel Lakdhar, Tunis 1005, Tunisia

7. Biotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, Doha 2713, Qatar

8. Department of Bacteriology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia

9. Legal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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