Identification of Up- and Down-Regulated Proteins in Pemetrexed-Resistant Human Lung Adenocarcinoma: Flavin Reductase and Calreticulin Play Key Roles in the Development of Pemetrexed-Associated Resistance

Author:

Chou Hsiu-Chuan1,Chen Jing-Yi2,Lin Dai-Ying2,Wen Yueh-Feng23,Lin Chi-Chen4567,Lin Sheng-Hao47,Lin Ching-Hsiung789,Chung Ting-Wen2,Liao En-Chi2,Chen Ying-Jen2,Wei Yu-Shan2,Tsai Yi-Ting2,Chan Hong-Lin2

Affiliation:

1. Department of Applied Science, National Hsinchu University of Education, No. 521, Nan-Da Road, Hsinchu 30014, Taiwan

2. Department of Medical Science and Institute of Bioinformatics and Structural Biology, National Tsing Hua University, No. 101, Kuang-Fu Road Sec. 2, Hsinchu 30013, Taiwan

3. Department of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, No. 25, Lane 442, Sec. 1, Jingguo Road, Hsinchu 30059, Taiwan

4. Institute of Biomedical Science, National Chung-Hsing University, No. 250, Guoguang Road, Taichung 402, Taiwan

5. Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, No. 250, Guoguang Road, Taichung 402, Taiwan

6. Department of Medical Research and Education, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan

7. Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, No. 480, Zhongzheng Road, Changhua 505, Taiwan

8. Department of Respiratory Care, College of Health Sciences, Chang Jung Christian University, No. 1, Changda Road, Tainan 71101, Taiwan

9. School of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo North Road, Taichung 40201, Taiwan

Funder

National Tsing Hua University

National Science Council Taiwan

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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