A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes-Reference-Cited by-同舟云学术

A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

Published:2022-01-04 Issue:3 Volume:21 Page:702-712
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

Moreno-Torres Marta¹^ORCID,Kumar Manoj²,García-Llorens Guillem¹³,Quintás Guillermo⁴⁵,Tricot Tine²,Boon Ruben²⁶⁷,Tolosa Laia¹,Toprakhisar Burak²,Chesnais Francois²⁸,Verfaillie Catherine²,Castell José V.¹⁵³⁹

Affiliation:

1. Unidad de Hepatología Experimental, Health Research Institute La Fe, Valencia 46026, Spain

2. Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven 3000, Belgium

3. Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia 46010, Spain

4. Health and Biomedicine, LEITAT Technological Center, Valencia 46026, Spain

5. Analytical Unit, Health Research Institute La Fe, Valencia 46026, Spain

6. Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston 02114, Massachusetts, United States

7. The Broad Institute, Harvard & MIT, Cambridge 02142, Massachusetts, United States

8. Academic Center of Reconstructive Science, King’s College London, London SE1 9RT, U.K.

9. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid 28029, Spain

Funder

KU Leuven

Ministerio de Ciencia e Innovaci??n

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Horizon 2020 Framework Programme

Instituto de Salud Carlos III

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.1c00779

Reference23 articles.

1. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

2. Competency of different cell models to predict human hepatotoxic drugs

3. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

4. Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells

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