A Two-Way Interaction between Methotrexate and the Gut Microbiota of Male Sprague

A Two-Way Interaction between Methotrexate and the Gut Microbiota of Male Sprague–Dawley Rats

Published:2020-06-16 Issue:8 Volume:19 Page:3326-3339
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

Letertre Marine P. M.¹^ORCID,Munjoma Nyasha²,Wolfer Kate¹,Pechlivanis Alexandros¹³⁴,McDonald Julie A. K.¹,Hardwick Rhiannon N.⁵,Cherrington Nathan J.⁵,Coen Muireann¹⁶,Nicholson Jeremy K.⁷,Hoyles Lesley¹⁸^ORCID,Swann Jonathan R.¹,Wilson Ian D.¹^ORCID

Affiliation:

1. Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College, London SW7 2AZ, U.K.

2. Waters Corporation, Wilmslow SK9 4AX, U.K.

3. Center for Interdisciplinary Research of the Aristotle University of Thessaloniki (KEDEK), 57001 Thessaloniki, Greece

4. Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

5. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tuscon, Arizona 85721, United States

6. Oncology Safety, Clinical Pharmacology & Safety Sciences, R&D, Astra Zeneca, Cambridge CB4 0WG, U.K.

7. Australian National Phenome Centre, Health Futures Institute, Murdoch University, Murdoch, WA 6150, Australia

8. Department of Biosciences, Nottingham Trent University, Nottingham NG11 8NS, U.K.

Funder

Medical Research Council

National Institute for Health Research

Servier

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.0c00230

Reference62 articles.

1. Very high-dose methotrexate (33.6 g/m2) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P

2. Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure

3. Mechanisms of action of methotrexate

4. The cellular pharmacology of methotrexate

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