Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson’s Disease

Author:

Ma Shi-Xun12,Seo Bo Am12,Kim Donghoon123,Xiong Yulan12,Kwon Seung-Hwan12,Brahmachari Saurav12,Kim Sangjune12,Kam Tae-In12,Nirujogi Raja Sekhar45,Kwon Sang Ho12,Dawson Valina L.12678,Dawson Ted M.12698,Pandey Akhilesh45101112ORCID,Na Chan Hyun12ORCID,Ko Han Seok12813

Affiliation:

1. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

3. Department of Pharmacology, Peripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan 49201, South Korea

4. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

5. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

6. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

7. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

8. Adrienne Helis Malvin Medical Research Foundation, New Orleans 70130, Louisiana, United States

9. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

10. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

11. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore 21205-2105, Maryland, United States

12. Department of Laboratory Medicine and Pathology, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 55905, United States

13. Diana Helis Henry Medical Research Foundation, New Orleans 70130, Louisiana, United States

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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