Establishing Personalized Blood Protein Reference Ranges Using Noninvasive Microsampling and Targeted Proteomics: Implications for Antidoping Strategies

Author:

Richard Vincent R.1,Mitsa Georgia12,Eshghi Azad3,Chaplygina Daria1,Mohammed Yassene4ORCID,Goodlett David R.3,Zahedi Rene P.5678ORCID,Thevis Mario910,Borchers Christoph H.121112ORCID

Affiliation:

1. Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Quebec H3T 1E2, Canada

2. Division of Experimental Medicine, McGill University, Montréal, Quebec H4A 3J1, Canada

3. University of Victoria-Genome BC Proteomics Centre, Victoria, British Columbia V8Z 7X8, Canada

4. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands

5. Manitoba Centre for Proteomics and Systems Biology, Winnipeg, Manitoba R3E 3P4, Canada

6. Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3P4, Canada

7. Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada

8. CancerCare Manitoba Research Institute, Winnipeg, Manitoba R3E 0V9, Canada

9. Institute of Biochemistry, Center for Preventive Doping Research, German Sport University Cologne, Cologne 50933, Germany

10. European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne/Bonn 50933, Germany

11. Gerald Bronfman Department of Oncology, McGill University, Montréal, Quebec H4A 3T2, Canada

12. Department of Pathology, McGill University, Montréal, Quebec H4A 3J1, Canada

Funder

McGill University

Partnership for Clean Competition

Genome Canada

Warren Y. Soper Charitable Trust

Fondation De Famille Alvin Segal

Publisher

American Chemical Society (ACS)

Reference40 articles.

1. The Athlete Biological Passport

2. Application of the Athlete's Performance Passport for Doping Control: A Case Report

3. The Athlete Biological Passport: How to Personalize Anti-Doping Testing across an Athlete's Career?

4. World_Anti-Doping_Agency_(WADA). Athlete Biological Passport (ABP) Operating Guidelines: https://www.wada-ama.org/en/resources/athlete-biological-passport/athlete-biological-passport-abp-operating-guidelines; 2018. Available from: https://www.wada-ama.org/sites/default/files/resources/files/guidelines_abp_v61_2018_jul_en.pdf.

5. Acute hyperhydration reduces athlete biological passport OFF-hr score

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