Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)-Reference-Cited by-同舟云学术

Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Published:2014-01-22 Issue:3 Volume:57 Page:770-792
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Giannetti Anthony M.¹,Zheng Xiaozhang²,Skelton Nicholas J.¹,Wang Weiru¹,Bravo Brandon J.¹,Bair Kenneth W.²,Baumeister Timm²,Cheng Eric¹,Crocker Lisa¹,Feng Yezhen³,Gunzner-Toste Janet¹,Ho Yen-Ching²,Hua Rongbao³,Liederer Bianca M.¹,Liu Yongbo³,Ma Xiaolei¹,O’Brien Thomas¹,Oeh Jason¹,Sampath Deepak¹,Shen Youming³,Wang Chengcheng⁴,Wang Leslie¹,Wu Hongxing³,Xiao Yang¹,Yuen Po-wai³,Zak Mark¹,Zhao Guiling¹,Zhao Qiang⁴,Dragovich Peter S.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Forma Therapeutics, Inc., 500 Arsenal Street, Watertown, Massachusetts 02472, Unites States

3. Pharmaron Beijing, Co. Ltd., 6 Taihe Road, BDA, Beijing, 100176, P. R. China

4. Crown Bioscience, Science and Technology Innovation Park, No. 6 Beijing West Road, Taicang City, Jiangsu Province, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4015108

Reference73 articles.

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2. The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

3. NAD+and Vitamin B3: From Metabolism to Therapies

4. Biosynthesis of Diphosphopyridine Nucleotide

5. NAMPT in Regulated NAD Biosynthesis and its Pivotal Role in Human Metabolism

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