Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist-Reference-Cited by-同舟云学术

Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist

Published:2007-10-19 Issue:23 Volume:50 Page:5535-5538
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cole Derek C.¹,Stock Joseph R.¹,Lennox William J.¹,Bernotas Ronald C.¹,Ellingboe John W.¹,Boikess Steve¹,Coupet Joseph¹,Smith Deborah L.¹,Leung Louis¹,Zhang Guo-Ming¹,Feng Xidong¹,Kelly Michael F.¹,Galante Rocco¹,Huang Pingzhong¹,Dawson Lee A.¹,Marquis Karen¹,Rosenzweig-Lipson Sharon¹,Beyer Chad E.¹,Schechter Lee E.¹

Affiliation:

1. Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, Chemical & Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, Discovery Neurosciences, Wyeth Research, Princeton, New Jersey 08852, and Drug Safety & Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070521y

Reference19 articles.

1. 5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture

2. The Putative 5-ht6 Receptor: Localization and Function

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