Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide-Reference-Cited by-同舟云学术

Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide

Published:2002-11-20 Issue:26 Volume:45 Page:5755-5775
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Madsen Peter¹,Ling Anthony¹,Plewe Michael¹,Sams Christian K.¹,Knudsen Lotte B.¹,Sidelmann Ulla G.¹,Ynddal Lars¹,Brand Christian L.¹,Andersen Birgitte¹,Murphy Douglas¹,Teng Min¹,Truesdale Larry¹,Kiel Dan¹,May John¹,Kuki Atsuo¹,Shi Shenghua¹,Johnson Michael D.¹,Teston Kimberly Ann¹,Feng Jun¹,Lakis James¹,Anderes Kenna¹,Gregor Vlad¹,Lau Jesper¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular Pharmacology, Exploratory ADME, Pharmacological Research, and Biochemistry and Metabolism, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark, and Departments of Medicinal Chemistry, Computational Chemistry, Combinatorial Chemistry Technology, and Pharmacology, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0208572

Reference27 articles.

1. Introduction

2. Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM

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