1. Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, Encysive Pharmaceuticals Inc., Houston Texas 77030, Genome Center, University of California, Davis, California 95616-8816, Burnham Institute for Medical Research, La Jolla, California 92037, Department of Chemistry, Stanford University, Stanford, California 94305, and Department of Pharmaceutical Chemistry, University of California, San Francisco